Midbrain SERT in degenerative parkinsonisms: A 123I‐FP‐CIT SPECT study
Identifieur interne : 001B83 ( Main/Exploration ); précédent : 001B82; suivant : 001B84Midbrain SERT in degenerative parkinsonisms: A 123I‐FP‐CIT SPECT study
Auteurs : Francesco Roselli [Italie, Allemagne] ; Nicola M. Pisciotta [Italie] ; Michele Pennelli [Italie] ; Maria S. Aniello [Italie] ; Angelo Gigante [Italie] ; Maria F. De Caro [Italie] ; Ermanno Ferrannini [Italie] ; Bruno Tartaglione [Italie] ; Artor Niccoli-Asabella [Italie] ; Giovanni Defazio [Italie] ; Paolo Livrea [Italie] ; Giuseppe Rubini [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-09-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- 123I‐FP‐CIT, Aged, Aged, 80 and over, Analysis of Variance, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Lewy body dementia, Magnetic Resonance Imaging, Male, Mesencephalon (metabolism), Mesencephalon (radionuclide imaging), Midbrain, Middle Aged, Movement Disorders (metabolism), Movement Disorders (radionuclide imaging), Nervous system diseases, Parkinsonism, Photon, SPECT, Serotonin Plasma Membrane Transport Proteins (metabolism), Serotonin transporter, Single photon emission tomography, dementia with Lewy bodies, parkinsonism, serotonin transporter.
- MESH :
- chemical , metabolism : Serotonin Plasma Membrane Transport Proteins.
- metabolism : Mesencephalon, Movement Disorders.
- radionuclide imaging : Mesencephalon, Movement Disorders.
- Aged, Aged, 80 and over, Analysis of Variance, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged.
Abstract
SPECT imaging is widely used for the differential diagnosis of degenerative parkinsonisms by exploiting the high affinitiy of the radiotracer 123I‐FP‐CIT for the dopamine transporter. Reduced levels of DAT are found in Parkinson Disease (PD), Dementia with Lewy Bodies (DLB), and Progressive Supranuclear Palsy (PSP) compared to in Essential Tremor (ET) and Healthy Controls (HC). However, the extent of the neurodegenerative process may extend beyond nigrostriatal system. We have exploited the affinity of the same radiotracer 123I‐FP‐CIT for the serotonin transporter to investigate SERT levels in the midbrain of patients with PD, DLB, PSP, and ET compared to HC. Using MRI images as anatomical templates for midbrain uptake quantification, we found a mild decrease in SERT levels in PD compared to ET and HC, with marked inter‐individual variability; on the other side, PSP and DLB patients displayed markedly reduced to undetectable levels of SERT, respectively. These findings show that the neurodegenerative process affects serotoninergic neurons in parkinsonisms, with much more severe involvement in DLB than in PD patients, despite the comparable loss of striatal DAT. SERT‐dependent 123I‐FP‐CIT uptake may allow a more comprehensive assessment of neurochemical disturbances in degenerative parkinsonisms and may have a value for differential diagnosis. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.23179
Affiliations:
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<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Analysis of Variance</term>
<term>Brain Mapping</term>
<term>Female</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Lewy body dementia</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Mesencephalon (metabolism)</term>
<term>Mesencephalon (radionuclide imaging)</term>
<term>Midbrain</term>
<term>Middle Aged</term>
<term>Movement Disorders (metabolism)</term>
<term>Movement Disorders (radionuclide imaging)</term>
<term>Nervous system diseases</term>
<term>Parkinsonism</term>
<term>Photon</term>
<term>SPECT</term>
<term>Serotonin Plasma Membrane Transport Proteins (metabolism)</term>
<term>Serotonin transporter</term>
<term>Single photon emission tomography</term>
<term>dementia with Lewy bodies</term>
<term>parkinsonism</term>
<term>serotonin transporter</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Serotonin Plasma Membrane Transport Proteins</term>
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<term>Movement Disorders</term>
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<term>Movement Disorders</term>
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<term>Aged, 80 and over</term>
<term>Analysis of Variance</term>
<term>Brain Mapping</term>
<term>Female</term>
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<front><div type="abstract" xml:lang="fr">SPECT imaging is widely used for the differential diagnosis of degenerative parkinsonisms by exploiting the high affinitiy of the radiotracer 123I‐FP‐CIT for the dopamine transporter. Reduced levels of DAT are found in Parkinson Disease (PD), Dementia with Lewy Bodies (DLB), and Progressive Supranuclear Palsy (PSP) compared to in Essential Tremor (ET) and Healthy Controls (HC). However, the extent of the neurodegenerative process may extend beyond nigrostriatal system. We have exploited the affinity of the same radiotracer 123I‐FP‐CIT for the serotonin transporter to investigate SERT levels in the midbrain of patients with PD, DLB, PSP, and ET compared to HC. Using MRI images as anatomical templates for midbrain uptake quantification, we found a mild decrease in SERT levels in PD compared to ET and HC, with marked inter‐individual variability; on the other side, PSP and DLB patients displayed markedly reduced to undetectable levels of SERT, respectively. These findings show that the neurodegenerative process affects serotoninergic neurons in parkinsonisms, with much more severe involvement in DLB than in PD patients, despite the comparable loss of striatal DAT. SERT‐dependent 123I‐FP‐CIT uptake may allow a more comprehensive assessment of neurochemical disturbances in degenerative parkinsonisms and may have a value for differential diagnosis. © 2010 Movement Disorder Society</div>
</front>
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<name sortKey="Niccoli Sabella, Artor" sort="Niccoli Sabella, Artor" uniqKey="Niccoli Sabella A" first="Artor" last="Niccoli-Asabella">Artor Niccoli-Asabella</name>
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